Product Detail
Product NameSEMA6C Antibody FITC Conjugated
Host SpeciesRabbit
ClonalityPolyclonal
IsotypeIgG
PurificationPurified by Protein A.
ApplicationsICC,IF
Species ReactivityHu Ms Rt
Immunogen DescKLH conjugated synthetic peptide derived from human SEMA6C
Target NameSEMA6C
ConjugateFITC
Excitation Emission494nm 518nm
Other NamesKIAA1869; m Sema Y; m Sema Y2; sema domain, transmembrane domain TM, and cytoplasmic domain, semaphorin 6C; Sema Y antibody Semaphorin 6C [Precursor]; Semaphorin Y; SEMAY; SEM6C_HUMAN.
Concentration1mg ml
Formulation0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
StorageShipped at 4˚C. Store at -20˚C for one year. Avoid repeated freeze/thaw cycles.
Application Details
ICC=1:50-200 IF=1:50-200
Semaphorins are a family of cell surface and secreted proteins involved in neural development that are conserved from insects to humans. Members of this family are approximately 750 amino acids in length (including signal sequences) and are defined by a conserved extracellular a?semaphorina? domain of approximately 500 amino acids containing 14-16 cysteines, blocks of conserved sequences and no obvious repeats. The transmembrane semaphorins are characterized by an additional 80 amino acid transmembrane domain and an 80-110 amino acid cytoplasmic domain. SEMA6C, also known as SEMA Y, is a transmembrane protein expressed in fetal brain and adult skeletal muscle. Three isoforms of this semaphorin exist due to alternative splicing: SEMA6C 1, SEMA6C 2 and SEMA6C 3. The extracellular domain of SEMA6C induces growth cone collapse of dorsal root ganglion and plays a role in generation or stability of entorhino-hippocampal synapses.
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