Product Detail
Product NameCyclin D2 Antibody FITC Conjugated
Host SpeciesRabbit
ClonalityPolyclonal
IsotypeIgG
PurificationPurified by Protein A.
ApplicationsFlow-Cyt,IF
Species ReactivityHu Ms Rt
Immunogen DescKLH conjugated synthetic peptide aa 150-200 288 derived from human Cyclin D2
Target NameCyclin D2
ConjugateFITC
Excitation Emission494nm 518nm
Other NamesMPPH3; KIAK2; G1 S-specific cyclin-D2; CCND2
Accession NoSwiss-Prot#P30279
NCBI Gene ID894
Uniprot
P30279
Gene ID
894;
Concentration1mg ml
Formulation0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
StorageShipped at 4˚C. Store at -20˚C for one year. Avoid repeated freeze/thaw cycles.
Application Details
Flow-Cyt=1:50-200 IF=1:50-200
Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1) S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D2 CDK4 CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex (By similarity).
If you have published an article using product C01247F, please notify us so that we can cite your literature.
15 business days.
