Product Detail
Product NameFrizzled 9 CD349 Antibody PE Conjugated
Host SpeciesRabbit
ClonalityPolyclonal
IsotypeIgG
PurificationPurified by Protein A.
ApplicationsICC IF
Species ReactivityHu Ms Rt
Immunogen DescKLH conjugated synthetic peptide aa 180-229 591 derived from human Frizzled 9 CD349
Target NameFrizzled 9 CD349
ConjugatePE
Excitation Emission480,565nm 578nm
Other NamesFZD3; CD349; Frizzled-9; Fz-9; hFz9; FzE6; FZD9
Accession NoSwiss-Prot#O00144
NCBI Gene ID8326
Uniprot
O00144
Gene ID
8326;
Concentration1mg ml
Formulation0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
StorageShipped at 4˚C. Store at -20˚C for one year. Avoid repeated freeze/thaw cycles.
Application Details
ICC=1:50-200 IF=1:50-200
Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and or in differentiated tissues.
If you have published an article using product C01531P, please notify us so that we can cite your literature.
15 business days.
