Product Detail
Product NamePDGFAA + PDGFBB Antibody HRP Conjugated
Host SpeciesRabbit
ClonalityPolyclonal
IsotypeIgG
PurificationPurified by Protein A.
ApplicationsWB IHC-P IHC-F ICC
Species ReactivityHu Ms Rt
Immunogen DescKLH conjugated synthetic peptide derived from human PDGFAA + PDGFBB
Target NamePDGFAA + PDGFBB
ConjugateHRP
Excitation EmissionN A
Other NamesBecaplermin ;c sis ;c-sis ;FLJ12858 ;PDGF 1 ;PDGF 2 ;PDGF A ;PDGF A chain ;PDGF B ;PDGF B chain ;PDGF subunit B ;PDGF-2 ;Pdgfb ;PDGFB_HUMAN ;Platelet derived growth factor A chain precursor ;Platelet derived growth factor alpha polypeptide ;Platelet derived growth factor B chain precursor ;Platelet
Concentration1mg ml
Formulation0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
StorageShipped at 4˚C. Store at -20˚C for one year. Avoid repeated freeze/thaw cycles.
Application Details
WB=1:500-2000 IHC-P=1:50-200 IHC-F=1:50-200 ICC=1:50-200
The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines. This gene product can exist either as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha polypeptide (PDGF-AB), where the dimers are connected by disulfide bonds. Mutations in this gene are associated with meningioma. Reciprocal translocations between chromosomes 22 and 7, at sites where this gene and that for COL1A1 are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans resulting from unregulated expression of growth factor. Two alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Oct 2008].
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