Product Detail
Product Namehuman Fibrinogen Antibody HRP Conjugated
Host SpeciesRabbit
ClonalityPolyclonal
IsotypeIgG
PurificationPurified by Protein A.
ApplicationsIHC
Species ReactivityHu Ms Rt
Immunogen DescFibrinogen from human plasma
Target Namehuman Fibrinogen
ConjugateHRP
Excitation EmissionN A
Other NamesFib2; Fibrinogen alpha chain; FGA
Accession NoSwiss-Prot#P02671
NCBI Gene ID2243
Uniprot
P02671
Gene ID
2243;
Concentration1mg ml
Formulation0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
StorageShipped at 4˚C. Store at -20˚C for one year. Avoid repeated freeze/thaw cycles.
Application Details
IHC-P=1:50-200 IHC-F=1:50-200
Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the immune response via both innate and T-cell mediated pathways.
If you have published an article using product C01982H, please notify us so that we can cite your literature.
15 business days.
