Product Detail
Product NameClaudin 16 Antibody FITC Conjugated
Host SpeciesRabbit
ClonalityPolyclonal
IsotypeIgG
PurificationPurified by Protein A.
ApplicationsICC IF
Species ReactivityHu Ms Rt
Immunogen DescKLH conjugated synthetic peptide aa 90-140 305 derived from human Claudin 16
Target NameClaudin 16
ConjugateFITC
Excitation Emission494nm 518nm
Other NamesHOMG3; PCLN1; Claudin-16; Paracellin-1; PCLN-1; CLDN16
Accession NoSwiss-Prot#Q9Y5I7
NCBI Gene ID10686
Uniprot
Q9Y5I7
Gene ID
10686;
Concentration1mg ml
Formulation0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
StorageShipped at 4˚C. Store at -20˚C for one year. Avoid repeated freeze/thaw cycles.
Application Details
ICC=1:50-200 IF=1:50-200
Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. Involved in paracellular magnesium reabsorption. Required for a selective paracellular conductance. May form, alone or in partnership with other constituents, an intercellular pore permitting paracellular passage of magnesium and calcium ions down their electrochemical gradients. Alternatively, it could be a sensor of magnesium concentration that could alter paracellular permeability mediated by other factors.
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