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Location： Home > Conjugated Antibodies > Estrogen Receptor alpha (Phospho-Tyr537) Antibody FITC Conjugated

Estrogen Receptor alpha (Phospho-Tyr537) Antibody FITC Conjugated#C03586F

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Product NameEstrogen Receptor alpha (Phospho-Tyr537) Antibody FITC Conjugated

Host SpeciesRabbit

ClonalityPolyclonal

IsotypeIgG

PurificationPurified by Protein A.

ApplicationsFlow-Cyt IF

Species ReactivityHu Ms Rt

Immunogen DescKLH conjugated synthetic phosphopeptide derived from human ER alpha around the phosphorylation site of Tyr537

Target NameEstrogen Receptor alpha Tyr537

ConjugateFITC

Excitation Emission494nm 518nm

Other NamesER alpha Tyr537; ER alpha Y537; ER alpha Y537; ER alpha Tyr537; p-ER alpha Tyr537; p-ER alpha Y537; Estrogen Receptor alpha Y537; Estrogen Receptor alpha Tyr537; Estradiol receptor; Estrogen receptor alpha; Estradiol Receptor-alpha; Estrogen Receptor 1; Atherosclerosis, susceptibility to, included;

Accession No
NCBI Gene ID2099

Uniprot P03372

Gene ID 2099;

Concentration1mg ml

Formulation0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

StorageShipped at 4˚C. Store at -20˚C for one year. Avoid repeated freeze/thaw cycles.

Application Details
Flow-Cyt=1:50-200 IF=1:50-200
Estrogen and progesterone receptor are members of a family of transcription factors that are regulated by the binding of their cognate ligands. The interaction of hormone-bound estrogen receptors with estrogen responsive elements(EREs) alters transcription of ERE-containing genes. The carboxy terminal region of the estrgen receptor contains the ligand binding domain, the amino terminus serves as the transactivation domain, and the DNA binding domain is centrally located. Two forms of estrogen receptor have been identified, ER Alpha and ER Beta. ER Alpha and ER Beta have been shown to be differentially activated by various ligands. The biological response to progesterone is mediated by two distinct forms of the human progesterone receptor (hPR-A and hPR-B), which arise from alternative splicing. In most cells, hPR-B functions as a transcriptional activator of progesterone-responsive gene, whereas hPR-A function as a transcriptional inhibitor of all steroid hormone receptors.

If you have published an article using product C03586F, please notify us so that we can cite your literature.

NOTE

Application

  • WBWestern Blotting
  • IHCImmunohistochemistry
  • IFImmunofluorescence
  • ICCImmunocytochemistry
  • FCFlow Cytometry
  • IPImmunoprecipitation
  • EELISA
  • DBDot Blotting
  • ChIPChromatin Immunoprecipitation
  • GICAGold Immunochromatography Assay
  • NCNegative Control

Species Reactivity

  • HuHuman
  • MsMouse
  • RtRat
  • DmDrosophila melanogaster
  • CCaenorhabditis elegans
  • MkMonkey
  • RbRabbit
  • BBovine
  • DDog
  • PPig
  • HmHamster
  • ChHmChinese Hamster
  • ChkChicken
  • ShpSheep
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