Product Detail
Product NamePlasminogen Antibody HRP Conjugated
Host SpeciesRabbit
ClonalityPolyclonal
IsotypeIgG
PurificationPurified by Protein A.
ApplicationsWB IHC-P IHC-F
Species ReactivityHu Ms Rt
Immunogen DescKLH conjugated synthetic peptide derived from human PLG
Target NamePlasminogen
ConjugateHRP
Excitation EmissionN A
Other NamesPlasminogen; Angiostatin; DKFZp779M0222; Microplasmin; Plasmin; Plasmin heavy chain A; PLG; PLMN_HUMAN.
Accession No
NCBI Gene ID5340
Uniprot
P00747
Gene ID
5340;
Concentration1mg ml
Formulation0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
StorageShipped at 4˚C. Store at -20˚C for one year. Avoid repeated freeze/thaw cycles.
Application Details
WB=1:500-2000 IHC-P=1:50-200 IHC-F=1:50-200
Plasminogen is a plasma protein synthesised mostly in the liver. Plasma concentration is usually in the range of 70 to 200mg l. Plasminogen is activated by tissue plasminogen activator, urokinase and streptokinase, to form plasmin. Activation results from the cleavage and release of the preactivation peptide. Angiostatin, an internal fragment of plasminogen, is a potent inhibitor of angiogenesis, which selectively inhibits endothelial cell proliferation. Angiostatin potently inhibits tumor growth and can maintain metastatic and primary tumors in a dormant state. It is defined by a balance of proliferation and apoptosis of the tumor cells and is composed of plasminogen first four cringle structures. This molecule is generated by proteolytic cleavage of plasminogen.
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