Product Detail
Product NameKi-67 (Proliferation Marker) Antibody FITC Conjugated
Host SpeciesRabbit
ClonalityPolyclonal
IsotypeIgG
PurificationPurified by Protein A.
ApplicationsFlow-Cyt
Species ReactivityHu Ms Rt Rab
Immunogen DescKLH conjugated synthetic peptide aa 1250-1300 3256 derived from human Ki67
Target NameKi-67 proliferation Marker
ConjugateFITC
Excitation Emission494nm 518nm
Other NamesKIA; MIB-; MIB-1; PPP1R15; Antigen KI-67; MKI67
Accession NoSwiss-Prot#P46013
NCBI Gene ID4288
Uniprot
P46013
Gene ID
4288;
Concentration1mg ml
Formulation0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
StorageShipped at 4˚C. Store at -20˚C for one year. Avoid repeated freeze/thaw cycles.
Application Details
Flow-Cyt=1:50-200
Proliferation Marker Ki67 antigen is the prototypic cell cycle related nuclear protein, expressed by proliferating cells in all phases of the active cell cycle (G1, S, G2 and M phase). It is absent in resting (G0) cells. Ki67 are useful in establishing the cell growing fraction in neoplasms (immunohistochemically quantified by determining the number of Ki67 positive cells among the total number of resting cells = Ki67 index). In neoplastic tissues the prognostic value is comparable to the tritiated thymidine labelling index. The correlation between low Ki67 index and histologically low grade tumours is strong. Ki67 is routinely used as a neuronal marker of cell cycling and proliferation.
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