Product Detail
Product NameDKK1 Antibody HRP Conjugated
Host SpeciesRabbit
ClonalityPolyclonal
IsotypeIgG
PurificationPurified by Protein A.
ApplicationsIHC-P IHC-F
Species ReactivityHu Ms Rt
Immunogen DescKLH conjugated synthetic peptide aa 207-247 266 derived from human DKK1
Target NameDKK1
ConjugateHRP
Excitation EmissionN A
Other NamesSK; DKK-1; Dickkopf-related protein 1; Dickkopf-1; hDkk-1; DKK1; UNQ492 PRO18
Accession NoSwiss-Prot#O94907
NCBI Gene ID22943
Uniprot
O94907
Gene ID
22943;
Concentration1mg ml
Formulation0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
StorageShipped at 4˚C. Store at -20˚C for one year. Avoid repeated freeze/thaw cycles.
Application Details
IHC-P=1:50-200 IHC-F=1:50-200
Antagonizes canonical Wnt signaling by inhibiting LRP5 6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5 6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.
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15 business days.
