Product Detail
Product NameADAR1 Antibody FITC Conjugated
Host SpeciesRabbit
ClonalityPolyclonal
IsotypeIgG
PurificationPurified by Protein A.
Applications IF
Species ReactivityHu Ms Rt
Immunogen DescKLH conjugated synthetic peptide derived from human ADAR1
Target NameADAR1
ConjugateFITC
Excitation Emission494nm 518nm
Other Names136kDa double stranded RNA binding protein; Adar 1; ADAR; Adar1; Adenosine deaminase RNA specic 1; Adenosine deaminase RNA specic; Adenosine deaminase that act on RNA; AV242451; Double stranded RNA specic adenosine deaminase; Double-stranded RNA-specic editase Adar; Drada; Dsh; Dsrad; dsRNA adenosin
Accession No
NCBI Gene ID103
Uniprot
P55265
Gene ID
103;
Concentration1mg ml
Formulation0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
StorageShipped at 4˚C. Store at -20˚C for one year. Avoid repeated freeze/thaw cycles.
Application Details
IF=1:50-200
ADAR1 converts adenosine to inosine in dsRNA, which destabilizes the dsRNA helix. This activity is important for various functions like site-specific RNA editing of transcripts of the glutamate receptors and modifying viral RNA genomes (which may be responsible for hypermutation of certain negative-stranded viruses, e.g., measles virus). ADAR1 also binds to short interfering RNAs (siRNA) without editing them and suppresses siRNA-mediated RNA interference. This protein is ubiquitously expressed, with the highest levels being found in brain and lung.
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15 business days.
