Product Detail
Product NameNotch 2 Antibody FITC Conjugated
Host SpeciesRabbit
ClonalityPolyclonal
IsotypeIgG
PurificationPurified by Protein A.
Applications IF
Species ReactivityHu Ms Rt
Immunogen DescKLH conjugated synthetic peptide aa 1570-1620 2471 derived from human Notch2
Target NameNotch 2
ConjugateFITC
Excitation Emission494nm 518nm
Other NameshN2; AGS2; HJCYS; Neurogenic locus notch homolog protein 2; Notch 2; NOTCH2
Accession NoSwiss-Prot#Q04721
NCBI Gene ID4853
Uniprot
Q04721
Gene ID
4853;
Concentration1mg ml
Formulation0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
StorageShipped at 4˚C. Store at -20˚C for one year. Avoid repeated freeze/thaw cycles.
Application Details
IF=1:50-200
Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). Involved in bone remodeling and homeostasis. In collaboration with RELA p65 enhances NFATc1 promoter activity and positively regulates RANKL-induced osteoclast differentiation.
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15 business days.
