Product Detail
Product NameDKK3 Antibody PE Conjugated
Host SpeciesRabbit
ClonalityPolyclonal
IsotypeIgG
PurificationPurified by Protein A.
ApplicationsIF
Species ReactivityHu Ms Rt
Immunogen DescKLH conjugated synthetic peptide aa 50-85 350 derived from human DKK3
Target NameDKK3
ConjugatePE
Excitation Emission480,565nm 578nm
Other NamesRIG; REIC; Dickkopf-related protein 3; Dickkopf-3; Dkk-3; hDkk-3; DKK3; UNQ258 PRO295
Accession NoSwiss-Prot#Q9UBP4
NCBI Gene ID27122
Uniprot
Q9UBP4
Gene ID
27122;
Concentration1mg ml
Formulation0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
StorageShipped at 4˚C. Store at -20˚C for one year. Avoid repeated freeze/thaw cycles.
Application Details
IF=1:50-200
Antagonizes canonical Wnt signaling by inhibiting LRP5 6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5 6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity).
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15 business days.
