Product Detail
Product NameCD161 Antibody FITC Conjugated
Host SpeciesRabbit
ClonalityPolyclonal
IsotypeIgG
PurificationPurified by Protein A.
ApplicationsFCM IF(IHC-P)
Species ReactivityHu
Immunogen DescKLH conjugated synthetic peptide aa 175-225 225 derived from human CD161 NK11
Target NameCD161
ConjugateFITC
Excitation Emission494nm 518nm
Other NamesNKR; CD161; CLEC5B; NKR-P1; NKRP1A; NKR-P1A; hNKR-P1A; Killer cell lectin-like receptor subfamily B member 1; C-type lectin domain family 5 member B; Natural killer cell surface protein P1A; KLRB1
Accession NoSwiss-Prot#Q12918
NCBI Gene ID3820
Uniprot
Q12918
Gene ID
3820;
Concentration1mg ml
Formulation10mM Tris Buffered Saline containing 1% BSA, 50% glycerol and 0.09% sodium azide.
Storage Store at 4C for 12 months.
Application Details
FCM: 1:20-100
Immunofluorescence: 1:50-200
Plays an inhibitory role on natural killer (NK) cells cytotoxicity. Activation results in specific acid sphingomyelinase SMPD1 stimulation with subsequent marked elevation of intracellular ceramide. Activation also leads to AKT1 PKB and RPS6KA1 RSK1 kinases stimulation as well as markedly enhanced T-cell proliferation induced by anti-CD3. Acts as a lectin that binds to the terminal carbohydrate Gal-alpha(1,3)Gal epitope as well as to the N-acetyllactosamine epitope. Binds also to CLEC2D LLT1 as a ligand and inhibits NK cell-mediated cytotoxicity as well as interferon-gamma secretion in target cells.
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