Product Detail
Product NameLck (Phospho Tyr505) Antibody APC Conjugated
Host SpeciesRabbit
ClonalityPolyclonal
Purificationaffinity purified by Protein A
Species Reactivity(predicted: Human, Mouse, Rat)
SpecificityThe antibody detects endogenous level of Lck only when phosphorylated at Tyr505
Immunogen TypePeptide
Immunogen DescKLH conjugated synthesised phosphopeptide derived from human Lck around the phosphorylation site of Tyr505: GQ(P-Y)QP
ConjugateAPC
Uniprot
P06239;
Gene ID
3932;
Calculated MWPredicted band size: 58 kDa </br>
Formulation0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
StorageShipped at 4˚C. Store at -20˚C for one year. Avoid repeated freeze/thaw cycles.
Application Details
This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein is a key signaling molecule in the selection and maturation of developing T-cells. It contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to the plasma membrane and pericentrosomal vesicles, and binds to cell surface receptors, including CD4 and CD8, and other signaling molecules. Multiple alternatively spliced variants, encoding the same protein, have been described. [provided by RefSeq, Jul 2008].
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