Product Detail
Product NamePI3 kinase p85 alpha + gamma (Phospho-Tyr467 + Tyr199) antibody HRP Conjugated
Host SpeciesRabbit
ClonalityPolyclonal
IsotypeIgG
PurificationPurified by Protein A.
ApplicationsWB IHC-P IHC-F
Species ReactivityHu Ms Rt
Immunogen DescKLH conjugated synthetic phosphopeptide aa 176-212 461 derived from human PI3K around the phosphorylation site of p85 alphaTyr467
Target NamePI3 kinase p85 alpha + gamma Tyr467 + Tyr199
ConjugateHRP
Excitation EmissionN A
Other Namesp85; AGM7; GRB1; IMD36; p85-ALPHA; Phosphatidylinositol 3-kinase regulatory subunit alpha; PI3-kinase regulatory subunit alpha; PI3K regulatory subunit alpha; PtdIns-3-kinase regulatory subunit alpha; Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha; PI3-kinase subunit p85-alpha; PtdIns
Accession NoSwiss-Prot#P27986
NCBI Gene ID5295
Uniprot
P27986
Gene ID
5295;
Concentration1mg ml
Formulation0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
StorageShipped at 4˚C. Store at -20˚C for one year. Avoid repeated freeze/thaw cycles.
Application Details
WB=1:500-2000 IHC-P=1:50-200 IHC-F=1:50-200
Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p11 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling.
If you have published an article using product C04630H, please notify us so that we can cite your literature.
et al,Identification of Cytochrome P450 2E1 as a Novel Target in Neuroinflammation and Development of Its Inhibitor Q11 as a Treatment Strategy.
, (2025),
PMID:
40122152
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