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Tau (Phospho-Thr181) Conjugated Antibody#C11107

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Product Detail

Product NameTau (Phospho-Thr181) Conjugated Antibody

Host SpeciesRabbit

ClonalityPolyclonal

Species ReactivityHu Ms Rt

SpecificityThe antibody detects endogenous level of Tau only when phosphorylated at threonine 181.

Immunogen DescPeptide sequence around phosphorylation site of threonine 181 (P-K-T(p)-P-P) derived from Human Tau.

ConjugateAF Dye

Excitation EmissionAF350: 346nm/442nm
AF405: 401nm/421nm
AF488: 493nm/519nm
AF555: 555nm/565nm
AF594: 591nm/614nm
AF647: 651nm/667nm
AF680: 679nm/702nm
AF750: 749nm/775nm

Other NamesMAPT;MTAPT;MTBT1;Neurofibrillary tangle protein;PHF-tau

Accession NoSwiss-Prot#:P10636
NCBI Gene ID:4137
NCBI mRNA#:NM_001123066.2
NCBI Protein#: NP _001116538.1

Uniprot P10636

Gene ID 4137;

Calculated MW48 62 78

Formulation0.01M Sodium Phosphate, 0.25M NaCl, pH 7.6, 5mg/ml Bovine Serum Albumin, 0.02% Sodium Azide

StorageStore at 4˚C in dark for 6 months

Application Details
Suggested Dilution:
AF350 conjugated: most applications: 1: 50 - 1: 250
AF405 conjugated: most applications: 1: 50 - 1: 250
AF488 conjugated: most applications: 1: 50 - 1: 250
AF555 conjugated: most applications: 1: 50 - 1: 250
AF594 conjugated: most applications: 1: 50 - 1: 250
AF647 conjugated: most applications: 1: 50 - 1: 250
AF680 conjugated: most applications: 1: 50 - 1: 250
AF750 conjugated: most applications: 1: 50 - 1: 250
Biotin conjugated: working with enzyme-conjugated streptavidin, most applications: 1: 50 - 1: 1,000
Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.

If you have published an article using product C11107, please notify us so that we can cite your literature.

et al,Cerebrospinal Fluid of Patients With Alzheimer's Disease Contains Increased Percentages of Synaptophysin-Bearing Microvesicles , (2021),
PMID: 34295239
et al,Fingolimod ameliorates amyloid deposition and neurodegeneration in APP/PS1 mouse model of Alzheimer's disease. , (2025),
PMID: 40158900

NOTE

Application

  • WBWestern Blotting
  • IHCImmunohistochemistry
  • IFImmunofluorescence
  • ICCImmunocytochemistry
  • FCFlow Cytometry
  • IPImmunoprecipitation
  • EELISA
  • DBDot Blotting
  • ChIPChromatin Immunoprecipitation
  • GICAGold Immunochromatography Assay
  • NCNegative Control

Species Reactivity

  • HuHuman
  • MsMouse
  • RtRat
  • DmDrosophila melanogaster
  • CCaenorhabditis elegans
  • MkMonkey
  • RbRabbit
  • BBovine
  • DDog
  • PPig
  • HmHamster
  • ChHmChinese Hamster
  • ChkChicken
  • ShpSheep
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