Product Detail
Product NameMouse IL-1a ELISA kit
ApplicationsELISA
Species ReactivityMs
SpecificityNatural and recombinant Mouse IL-1a Ligand
Target NameMouse IL-1a
Application Details
Detect Range: 1.8 - 125 pg/mL
Sensitivity: 1pg/mL
Sample Type: Cell culture supernatant, serum, plasma (EDTA, citrate, heparin)
Sample Volume: 20 uL
Assay Time: 3 hour
Detection method: Colorimetric
Representative standard curve for IL-1α ELISA. IL-1α was diluted in serial two-fold steps in Sample Diluent.
Interleukin-1 alpha(IL-1a) is a proinflammatory cytokine produced by a wide variety of cell types, including macrophages, osteoblasts, monocytes and hepatocytes. IL-1 alpha is synthesized as 31 kDa precursors that are subsequently cleaved into proteins with molecular weights of approximately 17 kDa. The IL-1a precursor reportedly shows full biological activity in the EL-4 assay. Circulating levels of IL-1a are normally low and only rise after stimulation by agents such as those produced byinflammation, infection or microbial endotoxins. IL-1a possesses a wide variety of biological activities and exerts its effects by binding to specific cell surface receptors.
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