Product Detail
Product NameAcetyl CoA Carboxylase 1(ACC1) Rabbit mAb
Clone No.ST53-08
Host SpeciesRabbit
ClonalityMonoclonal
PurificationProA affinity purified
ApplicationsWB, IHC
Species ReactivityHu, Ms, Rt
Immunogen Descrecombinant protein
ConjugateUnconjugated
Other NamesACAC antibody
ACACA antibody
ACACA_HUMAN antibody
ACACB antibody
ACC alpha antibody
ACC antibody
ACC beta antibody
ACC-alpha antibody
ACC1 antibody
ACC2 antibody
ACCA antibody
ACCB antibody
Acetyl CoA carboxylase 1 antibody
Acetyl CoA carboxylase 2 antibody
Acetyl CoA carboxylase alpha antibody
Acetyl CoA carboxylase beta antibody
Acetyl Coenzyme A carboxylase alpha antibody
Acetyl Coenzyme A carboxylase beta antibody
Biotin carboxylase antibody
COA1 antibody
COA2 antibody
HACC275 antibody
OTTHUMP00000164069 antibody
OTTHUMP00000164070 antibody
OTTHUMP00000164076 antibody
OTTHUMP00000240532 antibody
Accession NoSwiss-Prot#:Q13085
Uniprot
Q13085
Gene ID
31;
Calculated MW265 kDa
Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
StorageStore at -20˚C
Application Details
WB: 1:1,000
IHC: 1:50-1:200
Immunohistochemical analysis of paraffin-embedded human kidney tissue using anti-Acetyl CoA Carboxylase 1 antibody. Counter stained with hematoxylin.
Immunohistochemical analysis of paraffin-embedded mouse placenta tissue using anti-Acetyl CoA Carboxylase 1 antibody. Counter stained with hematoxylin.
Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. Exercise diminishes the activity of acetyl-CoA carboxylase in human muscle. ACCα (ACC1) is the rate-limiting enzyme in the biogenesis of long-chain fatty acids, and ACCβ (ACC2) may control mitochondrial fatty acid oxidation. These two isoforms of ACC control the amount of fatty acids in the cells. The catalytic function of ACCα is regulated by phosphorylation (inactive) and dephosphorylation (active) of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA, which serve as the enzymes short-term regulatory mechanism. The gene encoding ACCα maps to human chromosome 17 and encodes a form of ACC, which is the major ACC in lipogenic tissues. The catalytic core of ACCβ is homologous to that of the ACCα, except for an additional peptide of about 150 amino acids at the N-terminus.
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