Product Detail
Product NameDLC1 (Phospho-Ser567) Antibody
Host SpeciesRabbit
ClonalityPolyclonal
PurificationAntibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
ApplicationsCustom antibody
Species ReactivityHu Ms Rt
Immunogen TypePeptide-KLH
Target NameDLC1
ConjugateUnconjugated
Other NamesDeleted in liver cancer 1 protein; STARD12; Rho GTPase-activating protein 7
Accession Nouniprot:Q96QB1
Calculated MW171kDa
FormulationSupplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
StorageStore at -20˚C for long term preservation (recommended). Store at 4˚C for short term use.
Application Details
Western blotting: 1:500~1:1000
Functions as a GTPase-activating protein for the small GTPases RHOA, RHOB, RHOC and CDC42, terminating their downstream signaling. This induces morphological changes and detachment through cytoskeletal reorganization, playing a critical role in biological processes such as cell migration and proliferation. Also functions in vivo as an activator of the phospholipase PLCD1. Active DLC1 increases cell migration velocity but reduces directionality.
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