Product Detail
Product NameWee1B Antibody
Host SpeciesRabbit
ClonalityPolyclonal
PurificationAntibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
ApplicationsCustom antibody
Species ReactivityMs
Immunogen TypePeptide-KLH
Target NameWee1B
ConjugateUnconjugated
Other NamesWee1-like protein kinase 1B; Wee2
Accession Nouniprot:Q66JT0
Calculated MW62kDa
FormulationSupplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
StorageStore at -20˚C for long term preservation (recommended). Store at 4˚C for short term use.
Application Details
Western blotting: 1:500~1:1000
Oocyte-specific protein tyrosine kinase that phosphorylates and inhibits CDK1 and acts as a key regulator of meiosis during both prophase I and metaphase II. Required to maintain meiotic arrest in oocytes during the germinal vesicle (GV) stage, a long period of quiescence at dictyate prophase I, by phosphorylating CDK1 at 'Tyr-15', leading to inhibit CDK1 activity and prevent meiotic reentry.
If you have published an article using product SAB349, please notify us so that we can cite your literature.
et al,Promotion effect of down-regulation of protein kinase Wee1B expression on mitosis of mouse one-cell-stage embryos
, (2014),
PMID:
Yes
