Product Detail
Product NameCBS (Phospho-Tyr484) Antibody
Host SpeciesRabbit
ClonalityPolyclonal
PurificationThe antibody was purified from rabbit serum by affinity purification via sequential chromatography on phospho-peptide and non-phospho-peptide affinity columns.
ApplicationsWB
Species ReactivityHM
SpecificityCBS(Phospho-Tyr484) Antibody detects endogenous levels of CBS only
when phosphorylated at Tyr484.
Immunogen DescA synthesized peptide derived from human CBS around the phosphorylation site of Tyr484.
ConjugateUnconjugated
Other NamesCystathionine beta-synthase; Beta-thionase; Serine sulfhydrase
Uniprot
P35520
Gene ID
102724560
Sdspage MW61kDa
Concentration1 mg/ml
FormulationRabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM
NaCl,0.02% sodium azide and 50% glycerol.
StorageStore at --20˚C/1 year
Application Details
Western Blot: 1/500 - 1/2000
Hydro-lyase catalyzing the first step of the transsulfuration pathway, where the hydroxyl group of L-serine is displaced by L-homocysteine in a beta-replacement reaction to form L-cystathionine, the precursor of L-cysteine. This catabolic route allows the elimination of L-methionine and the toxic metabolite L-homocysteine (PubMed:23981774, PubMed:20506325, PubMed:23974653). Also involved in the production of hydrogen sulfide, a gasotransmitter with signaling and cytoprotective effects on neurons (By similarity).
If you have published an article using product SAB628, please notify us so that we can cite your literature.
Yes
