Product Detail
Product NameSQSTM1/p62 (Phospho-Ser) Antibody
Host SpeciesRabbit
ClonalityPolyclonal
PurificationThe antibody was purified from rabbit serum by affinity purification via sequential chromatography on phospho-peptide and non-phospho-peptide affinity columns.
ApplicationsWB
Species ReactivityHuman
SpecificitySQSTM1/p62(Phospho-Ser28) Antibody detects endogenous levels of NFKBIA only
when phosphorylated at Ser28.
Immunogen DescA synthesized peptide derived from human SQSTM1/p62 around the phosphorylation site of Ser28.
ConjugateUnconjugated
Other NamesSQSTM1,ORCA, OSIL,Sequestosome-1,Ubiquitin-binding protein p62,EBIAP
Uniprot
Q13501
Gene ID
8878
Calculated MW47kd
Concentration1 mg/ml
FormulationRabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM
NaCl,0.02% sodium azide and 50% glycerol.
StorageStore at --20˚C/1 year
Application Details
Western Blot: 1/500 - 1/2000
Autophagy receptor required for selective macroautophagy (aggrephagy). Functions as a bridge between polyubiquitinated cargo and autophagosomes. Interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family (PubMed:16286508, PubMed:20168092, PubMed:24128730, PubMed:28404643, PubMed:22622177). Along with WDFY3, involved in the formation and autophagic degradation of cytoplasmic ubiquitin-containing inclusions (p62 bodies, ALIS/aggresome-like induced structures). Along with WDFY3, required to recruit ubiquitinated proteins to PML bodies in the nucleus
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