PGC-1a (Mono-methyl-K224) Antibody - SAB

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PGC-1a (Mono-methyl-K224) Antibody#SAB651

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Catalog No. Package Size Price Quantity

SAB651 100ul $399.00

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Product Detail

Product NamePGC-1a (Mono-methyl-K224) Antibody

Host SpeciesRabbit

ClonalityPolyclonal

PurificationThe antibody was purified from rabbit serum by affinity purification via sequential chromatography on phospho-peptide and non-phospho-peptide affinity columns.

ApplicationsWB

Species ReactivityHuman

SpecificityPGC-1a (Mono-methyl-K224) Antibody detects endogenous levels of PGC-1a only when mono-methylated at lysine 224.

Immunogen DescA synthesized peptide derived from human PGC-1a around the mono-methylation site of K224.

ConjugateUnconjugated

Other NamesPGC-1-alpha, PPAR-gamma coactivator 1-alpha,PPARGC-1-alpha,Ligand effect modulator 6,LEM6, PGC1, PGC1A, PPARGC1

Uniprot Q9UBK2

Gene ID 10891

Sdspage MW91kDa

Concentration1 mg/ml

FormulationRabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl,0.02% sodium azide and 50% glycerol.

StorageStore at --20˚C/1 year

Application Details

Western Blot: 1/500 - 1/2000

Transcriptional coactivator for steroid receptors and nuclear receptors. Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter. Can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis. Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism. Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner. Also involved in the integration of the circadian rhythms and energy metabolism. Required for oscillatory expression of clock genes, such as ARNTL/BMAL1 and NR1D1, through the coactivation of RORA and RORC, and metabolic genes, such as PDK4 and PEPCK.

If you have published an article using product SAB651, please notify us so that we can cite your literature.

et al,KDM3A Senses Oxygen Availability to Regulate PGC-1α-Mediated Mitochondrial Biogenesis , (2019),
PMID: 31629659

NOTE

Application

WBWestern Blotting
IHCImmunohistochemistry
IFImmunofluorescence
ICCImmunocytochemistry
FCFlow Cytometry
IPImmunoprecipitation
EELISA
DBDot Blotting
ChIPChromatin Immunoprecipitation
GICAGold Immunochromatography Assay
NCNegative Control

Species Reactivity

HuHuman
MsMouse
RtRat
DmDrosophila melanogaster
CCaenorhabditis elegans
MkMonkey
RbRabbit
BBovine
DDog
PPig
HmHamster
ChHmChinese Hamster
ChkChicken
ShpSheep

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