Product Detail
Product NameYY1 (Phospho-Ser187) Antibody
Host SpeciesRabbit
ClonalityPolyclonal
PurificationThe antibody was purified from rabbit serum by affinity purification via sequential chromatography on phospho-peptide and non-phospho-peptide affinity columns.
ApplicationsWB
Species ReactivityHuman
SpecificityYY1(Phospho-Ser187) Antibody detects endogenous levels of YY1( only
when phosphorylated at Ser187.
Immunogen DescA synthesized peptide derived from human YY1 around the phosphorylation site of Ser187.
ConjugateUnconjugated
Other NamesYY1,INO80S,NF-E1,YY-1,Delta transcription factor
Uniprot
P25490
Gene ID
7528
Sdspage MW44kDa
Concentration1 mg/ml
FormulationRabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl,0.02% sodium azide.
StorageStore at --20˚C/1 year
Application Details
Western Blot: 1/500 - 1/2000
Multifunctional transcription factor that exhibits positive and negative control on a large number of cellular and viral genes by binding to sites overlapping the transcription start site. Binds to the consensus sequence 5'-CCGCCATNTT-3'; some genes have been shown to contain a longer binding motif allowing enhanced binding; the initial CG dinucleotide can be methylated greatly reducing the binding affinity. The effect on transcription regulation is depending upon the context in which it binds and diverse mechanisms of action include direct activation or repression, indirect activation or repression via cofactor recruitment, or activation or repression by disruption of binding sites or conformational DNA changes. Its activity is regulated by transcription factors and cytoplasmic proteins that have been shown to abrogate or completely inhibit YY1-mediated activation or repression.
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