Product Detail
Product NameNFKBIA (Phospho-Thr291) Antibody
Host SpeciesRabbit
ClonalityPolyclonal
PurificationThe antibody was purified from rabbit serum by affinity purification via sequential chromatography on phospho-peptide and non-phospho-peptide affinity columns.
ApplicationsWB
Species ReactivityHuman
SpecificityNFKBIA (Phospho-Thr291) Antibody detects endogenous levels of NFKBIA only
when phosphorylated at threonine 291.
Immunogen DescA synthesized peptide derived from human NFKBIA around the phosphorylation site of T291.
ConjugateUnconjugated
Other NamesNF-kappa-B inhibitor alpha,I-kappa-B-alpha,IkB-alpha,
IkappaBalpha
Uniprot
P25963
Gene ID
4792
Sdspage MW36kSa
Concentration1 mg/ml
FormulationRabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl,0.02% sodium azide.
StorageStore at --20˚C/1 year
Application Details
Western Blot: 1/500 - 1/2000
Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription.
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Yes
