• Product NameGluR2 (Ab-880) antibody
• Host SpeciesRabbit
• ClonalityPolyclonal
• PurificationAntibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
• ApplicationsWB
• Species ReactivityHu Ms Rt
• SpecificityThe antibody detects endogenous level of total Glutamate receptor 2 (Precursor) protein.
• Immunogen TypePeptide-KLH
• Immunogen DescriptionPeptide sequence around aa.878~882 (I-E-S-V-K) derived from Human Glutamate receptor 2.
• Target NameGluR2
• Alternative Names    GRIA2; GluR-2; GluR-B; GluR-K2; AMPA 2
• Accession No. Swiss-Prot: P42262
  NCBI Protein: NP_000817.2
• UniprotP42262
• Gene ID2891;
• SDS-PAGE MW 100kd
• Concentration 1.0mg/ml
• Formulation Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Storage Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.

• Predicted MW: 100kd
  Western blotting: 1:500~1:1000

Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist.

Cull-Candy, S. et al. (2006) Curr. Opin. Neurobiol. 16, 288-297.
Hanley JG, et al. (2002) Neuron. 34(1): 53-67

• Western blot analysis of extracts from mouse brain and rat brain tissue using GluR2 (Ab-880) antibody #21284.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting