• Product NameSH2B2 Antibody
• Host SpeciesRabbit
• ClonalityPolyclonal
• PurificationAntigen affinity purification.
• ApplicationsIHC
• Species ReactivityHu
• SpecificityThe antibody detects endogenous levels of total SH2B2 protein.
• Immunogen TypePeptide
• Immunogen DescriptionSynthetic peptide corresponding to residues near the C terminal of human SH2B adaptor protein 2
• Target NameSH2B2
• Alternative Names    APS
• Accession No. Swiss-Prot#: O14492
  NCBI Gene ID: 10603
  Gene Accssion: NP_066189
• UniprotO14492
• Gene ID10603;
• Concentration 4.3mg/ml
• Formulation Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
• Storage Store at -20˚C

• Immunohistochemistry: 1:25-1:100

The protein encoded by this gene is expressed in B lymphocytes and contains pleckstrin homology and src homology 2 (SH2) domains. In Burkitt's lymphoma cell lines, it is tyrosine-phosphorylated in response to B cell receptor stimulation. Because it binds Shc independent of stimulation and Grb2 after stimulation, it appears to play a role in signal transduction from the receptor to the Shc/Grb2 pathway.

• Immunohistochemical analysis of paraffin-embedded Human breast cancer tissue using #37426 at dilution 1/30.
• Immunohistochemical analysis of paraffin-embedded Human esophagus cancer tissue using #37426 at dilution 1/30.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting