• Product NameDENND1B Antibody
• Host SpeciesRabbit
• ClonalityPolyclonal
• PurificationAntigen affinity purification
• ApplicationsIHC
• Species ReactivityHu
• SpecificityThe antibody detects endogenous levels of total DENND1B protein.
• Immunogen Typeprotein
• Immunogen DescriptionFusion protein of human DENND1B
• Target NameDENND1B
• Alternative Names    FAM31B; C1ORF18; C1orf218
• Accession No. Swiss-Prot#:Q6P3S1
  NCBI Gene ID:163486
  Gene Accssion:BC022561
• UniprotQ6P3S1
• Gene ID163486;
• Concentration 0.7mg/ml
• Formulation Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
• Storage Store at -20C

• 
  Immunofluorescence:1: 20-100

Clathrin (see MIM 118955)-mediated endocytosis is a major mechanism for internalization of proteins and lipids. Members of the connecdenn family, such as DENND1B, function as guanine nucleotide exchange factors (GEFs) for the early endosomal small GTPase RAB35 (MIM 604199) and bind to clathrin and clathrin adaptor protein-2 (AP2; see MIM 601024). Thus, connecdenns link RAB35 activation with the clathrin machinery (Marat and McPherson, 2010 [PubMed 20154091]).

• The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using 47045(DENND1B Antibody) at dilution 1/20. (Original magnification: ?00)
• The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using 47045(DENND1B Antibody) at dilution 1/20. (Original magnification: ?00)

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting