• Product NameHuman CA125,MUC16 ELISA Kit
• SpecificityHuman
• Crossing ReactivityThere is no detectable cross-reactivity with other relevant proteins.
• Alternative Names    Mucin-16; MUC-16; Ovarian cancer-related tumor marker CA125; CA-125; Ovarian carcinoma antigen CA125; MUC16; CA125;
• Accession No. Q8WXI7
• UniprotQ8WXI7
• Gene ID94025;
• Cell Localization Cell membrane; May be liberated intothe extracellular space following the phosphorylation of theintracellular C-terminus which induces the proteolytic cleavageand liberation of the extracellular domain.

• sensitivity:10pg ml
  Detect Range:15.6pg/ml-1000pg/ml
  sample_type:cell culture supernates serum plasma(heparin EDTA) saliva urine and human milk.
  capture_antibody:
  detection_antibody:
  gene_name:MUC16
  protein_name:Mucin-16
  gene_full_name:Mucin-16
  tissue_specificity: Expressed in corneal and conjunctivalepithelia (at protein level). Overexpressed in ovarian carcinomasand ovarian low malignant potential (LMP) tumors as compared tothe expression in normal ovarian tissue and ovarian adenomas..
  sequence_similarities:
  tmb_incubation:20-25min
  research_category:tags & cell markers|cell type markers|tumor associated|signal transduction|cytoskeleton / ecm|extracellular matrix|ecm proteins|muc|cancer|invasion/microenvironment|tumor biomarkers|tumor antigens

• Sandwich High Sensitivity ELISA kit for Quantitative Detection of Human CA125,MUC16

protein_function: Thought to provide a protective, lubricating barrieragainst particles and infectious agents at mucosal surfaces..
CA-125, also known as mucin 16 or MUC16, is a protein that in humans is encoded by the MUC16 gene. MUC16 is a member of the mucin family glycoproteins. It is a component of the ocular surface, the respiratory tract and the female reproductive tract epithelia. Since MUC16 is highly glycosylated it creates a hydrophilic environment that acts as a lubricating barrier against foreign particles and infectious agents on the apical membrane of epithelial cells. Also, the cytoplasmic tail of MUC16 has been shown to interact with cytoskeleton by binding members of the ERM protein family. The expression of mucin 16 has been shown to be altered in dry eye, cystic fibrosis, and several types of cancers.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting