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Tau(Phospho-Thr231) Antibody #11110

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Catalog No. Package Size Price Quantity
50ul $219.00
100ul $319.00
Availability:Yes
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Description
  • Product NameTau(Phospho-Thr231) Antibody
  • Host SpeciesRabbit
  • ClonalityPolyclonal
  • PurificationAntibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
  • ApplicationsWB IHC
  • Species ReactivityHu Ms Rt
  • SpecificityThe antibody detects endogenous level of Tau only when phosphorylated at threonine 231.
  • Immunogen TypePeptide-KLH
  • Immunogen DescriptionPeptide sequence around phosphorylation site of threonine 231 (V-R-T(p)-P-P) derived from Human Tau.
  • Target NameTau
  • ModificationPhospho
  • Alternative Names    MAPT; MTAPT; MTBT1; Neurofibrillary tangle protein; PHF-tau
  • Accession No. Swiss-Prot: P10636
    NCBI Protein: NP _001116538.1
  • UniprotP10636
  • Gene ID4137;
  • Concentration 1.0mg/ml
  • Formulation Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.
Application Details
Background

Published Papers

Complement C3a receptor antagonist alleviates tau pathology and ameliorates cognitive deficits in P301S miceInBrain Res BullOn2023 AugbyYi Yao?1,?Yanmin Chang et al..PMID:?37330021, , (2023),
PMID: 37330021
Elevated Levels of Naturally-Occurring Autoantibodies Against the Extracellular Domain of p75NTR Aggravate the Pathology of Alzheimer's DiseaseInNeurosci BullOn2023 FebbyChen-Yang He?1?2,?Ding-Yuan Tian et al..PMID: 35974288, , (2023),
PMID: 35974288
Inhibiting α1-adrenergic Receptor Signaling Pathway Ameliorates Alzheimer��s Disease Type Pathologies and Behavioral Deficits in an AD Mouse Model. In J Neurochem on 2022 May by Zhong-Yuan Yu, Xu Yi, et al..PMID:35244207, , (2022),
PMID: 35244207
Yuan?zhi?san inhibits tau protein aggregation in an Aβ1?40?induced Alzheimer's disease rat model via the ubiquitin?proteasome system. In Mol Med Rep on 2021 Apr by Bin Li, Pei-Jun Xie,et al..PMID:33604685, , (2021),
PMID: 33604685
View All Published Papers A CRISPR-Cas13a system for efficient and specific therapeutic targeting of mutant KRAS for pancreatic cancer treatment.In J Evid Based Integr Med.On 2018 Jan-Dec by Zhong P, Yang H et al..PMID:30045633, , (2020),
PMID: 30045633
Nuclear PGK1 Alleviates ADP-Dependent Inhibition of CDC7 to Promote DNA Replication.In Mol Cell.On 2018 Nov 15 by Li X, Qian X et al..PMID:30392930, , (2020),
PMID: 30392930
Intraperitoneal Administration of Monoclonal Antibody Against Pathologic Aβ42 Aggregates Alleviated Cognitive Deficits and Synaptic Lesions in APP/PS1 Mice. In J Alzheimers Dis on 2020 by Shuo Xiao, Lin-Lin Song,,et al..PMID:31839610, , (2020),
PMID: 31839610
FoxO1 overexpression reduces Aβ production and tau phosphorylation in vitro. In Neurosci Lett on 2020 Nov 1 by Wei Zhang, Shanshan Bai,et al..PMID:32860886, , (2020),
PMID: 32860886
Capsaicin consumption reduces brain amyloid-beta generation and attenuates Alzheimer's disease-type pathology and cognitive deficits in APP/PS1 mice. In Transl Psychiatry on 2020 Jul 13 by Jun Wang, Bin-Lu Sun,et al..PMID:32661266, , (2020),
PMID: 32661266
MAPT/Tau accumulation represses autophagy flux by disrupting IST1-regulated ESCRT-III complex formation: a vicious cycle in Alzheimer neurodegeneration. In Autophagy on 2020 Apr by Qiong Feng, Yu Luo, et al..PMID:31223056, , (2020),
PMID: 31223056
A CRISPR-Cas13a system for efficient and specific therapeutic targeting of mutant KRAS for pancreatic cancer treatment.In J Evid Based Integr Med.On 2018 Jan-Dec by Zhong P, Yang H et al..PMID:30045633, , (2019),
PMID: 30045633
Protective effects of Coreopsis tinctoria flowers phenolic extract against D-galactosamine/lipopolysaccharide -induced acute liver injury by up-regulation of Nrf2, PPARα, and PPARγ.In Food Chem Toxicol. On 2018 Nov by Tian Y, Li Y et al..PMID:30236599, , (2019),
PMID: 30236599
Pyridostigmine protects against cardiomyopathy associated with adipose tissue browning and improvement of vagal activity in high-fat diet rats.InBiochim Biophys Acta Mol Basis Dis.On 2018 Apr by Lu Y, Wu Q et al..PMID:29309922, , (2019),
PMID: 29309922
Metformin attenuates triglyceride accumulation in HepG2 cells through decreasing stearyl-coenzyme A desaturase 1 expression.In Lipids Health Dis.On 2018 May 14 by Zhu X, Yan H Y et al..PMID: 29759071, , (2019),
PMID: 29759071
Tau-Induced Ca2+/Calmodulin-Dependent Protein Kinase-IV Activation Aggravates Nuclear Tau Hyperphosphorylation .In Neurosci Bull. On 2018 Apr by Wei YP, Ye JW et al..PMID: 28646348, , (2018),
PMID: 28646348
CXCL16 is activated by p-JNK and is involved in H2O2-induced HK-2 cell injury via p-ERK signaling.In Am J Transl Res. On 2018 Nov 15 by Zhang W, Hua T et al..PMID:30662622 , , (2018),
PMID: 30662622
Lnc RNA SNHG20 participated in proliferation, invasion, and migration of breast cancer cells via miR-495.In J Cell Biochem.On 2018 Nov by Guan YX, Zhang MZ et al..PMID:29236315, , (2018),
PMID: 29236315
Metformin attenuates triglyceride accumulation in HepG2 cells through decreasing stearyl-coenzyme A desaturase 1 expression.In Lipids Health Dis.On 2018 May 14 by Zhu X, Yan H Y et al..PMID: 29759071, , (2018),
PMID: 29759071
Tau-Induced Ca2+/Calmodulin-Dependent Protein Kinase-IV Activation Aggravates Nuclear Tau Hyperphosphorylation .In Neurosci Bull. On 2018 Apr by Wei YP, Ye JW et al..PMID: 28646348, , (2018),
PMID: 28646348
Cnga2 Knockout Mice Display Alzheimer's-Like Behavior Abnormities and Pathological Changes .In Mol Neurobiolon 2016 Sep by Ao-Ji Xie, En-Jie Liu et al..PMID: 26377105, , (2016),
PMID: 26377105
Sex dimorphism profile of Alzheimer's disease-type pathologies in an APP/PS1 mouse model.In Neurotox Res on 2016 Feb by Shu-Sheng Jiao, Xian-Le Bu et al..PMID:26707129, , (2016),
PMID: 26707129
Intramuscular delivery of p75 NTR ectodomain by an AAV vector attenuates cognitive deficits and Alzheimer's disease-like pathologies in APP/PS 1 transgenic mice. In J Neurochem on 2016 Jul by Qing-Hua Wang, Ye-Ran Wang,et al..PMID:26991827, , (2016),
PMID: 26991827
Extra-virgin olive oil attenuates amyloid-β and tau pathologies in the brains of TgSwDI mice. In J Nutr Biochem on 2015 Dec by Hisham Qosa, Loqman A Mohamed,et al..PMID:26344778, , (2015),
PMID: 26344778
FLZ alleviates the memory deficits in transgenic mouse model of Alzheimer's disease via decreasing beta-amyloid production and tau hyperphosphorylation. In PLoS One on 2013 Nov 4 by Xiu-Qi Bao, Ning Li, et al..PMID: 24223757, , (2013),
PMID: 24223757
Neuroglobin attenuates Alzheimer-like tau hyperphosphorylation by activating Akt signaling.In J Neurochem on 2012 Jan by Chen LM, Xiong YS,et al..PMID:21496024, , (2012),
PMID: 21496024
Synaptic released zinc promotes tau hyperphosphorylation by inhibition of protein phosphatase 2A (PP2A). In J Biol Chem on 2012 Mar 30 by Xu-Ying Sun, Yu-Ping Wei, et al..PMID: 22334661 , , (2012),
PMID: 22334661
Please let us know if you have published research using #11110 so that we can cite your reference.

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Application

WBWestern Blotting

IHCImmunohistochemistry

IFImmunofluorescence

ICCImmunocytochemistry

FCFlow Cytometry

IPImmunoprecipitation

EELISA

DBDot Blotting

ChIPChromatin Immunoprecipitation

GICAGold Immunochromatography Assay

NCNegative Control

Species Reactivity

HuHuman

MsMouse 

RtRat 

Dm Drosophila melanogaster

C Caenorhabditis elegans

MkMonkey

RbRabbit

B Bovine 

D Dog

PPig

HmHamster

ChHm Chinese Hamster 

ChkChicken  

ShpSheep