Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation.
Obestatin may be the ligand for GPR39. May have an appetite-reducing effect resulting in decreased food intake. May reduce gastric emptying activity and jejunal motility
"Ghrelin is a growth-hormone-releasing acylated peptide from stomach."
Kojima M., Hosoda H., Date Y., Nakazato M., Matsuo H., Kangawa K.
Nature 402:656-660(1999)
Research Topic:Cardiovascular