Regulates G protein-coupled receptor signaling cascades, including signaling downstream of the muscarinic acetylcholine receptor CHRM2. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Modulates the activity of potassium channels that are activated in response to CHRM2 signaling. Activity on GNAZ is inhibited by palmitoylation of the G-protein
"RGS10 is a selective activator of G alpha i GTPase activity."
Hunt T.W., Fields T.A., Casey P.J., Peralta E.G.
Nature 383:175-177(1996)
Research Topic:Signal Transduction