• Product NameReceptor-interacting serine/threonine-protein kinase 3
• Brief DescriptionRecombinant Protein
• Host SpeciesE.coli
• PurificationGreater than 90% by SDS-PAGE
• Species ReactivityRat
• Immunogen DescriptionRecombinant protein
• Alternative Names    Rip3,Homocysteine respondent protein HCYP2,RIP-like protein kinase 3,Receptor-interacting protein 3,RIP-3
• Accession No. Q9Z2P5
  Gene name:Ripk3
• UniprotQ9Z2P5
• Gene ID246240;
• Tag Info His
• Formulation 50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole,10%glycerol(PH8.0)
• Storage Store at -20C. (Avoid repeated freezing and thawing.)
  Repeated freezing and thawing is not recommended. Store working aliquots at 4˚C for up to one week.

Essential for necroptosis, a programmed cell death process in response to death-inducing TNF-alpha family members. Upon induction of necrosis, RIPK3 interacts with, and phosphorylates RIPK1 and MLKL to form a necrosis-inducing complex. RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL. These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production.

Repeated freezing and thawing is not recommended. Store working aliquots at 4˚C for up to one week.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting