• Product NameWilms tumor protein homolog
• Brief DescriptionRecombinant Protein
• Host SpeciesE.coli
• PurificationGreater than 90% by SDS-PAGE
• Species ReactivityMouse
• Immunogen DescriptionRecombinant protein
• Alternative Names    Wt-1
• Accession No. P22561
  Gene name:Wt1
• UniprotP22561
• Tag Info His
• Formulation 50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole,10%glycerol(PH8.0)
• Storage Store at -20C. (Avoid repeated freezing and thawing.)
  Repeated freezing and thawing is not recommended. Store working aliquots at 4˚C for up to one week.

Transcription factor that plays an important role in cellular development and cell survival (PubMed:16467207, PubMed:16920711, PubMed:17537799). Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3' (By similarity). Regulates the expression of numerous target genes, including EPO (PubMed:16467207). Plays an essential role for development of the urogenital system. It has a tumor suppressor as well as an oncogenic role in tumor formation. Function may be isoform-specific: isoforms lacking the KTS motif may act as transcription factors. Isoforms containing the KTS motif may bind mRNA and play a role in mRNA metabolism or splicing (PubMed:17167543). Isoform 1 has lower affinity for DNA, and can bind RNA.

Repeated freezing and thawing is not recommended. Store working aliquots at 4˚C for up to one week.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting