• Product NameNACHT, LRR and PYD domains-containing protein 3
• Brief DescriptionRecombinant Protein
• Host SpeciesE.coli
• PurificationGreater than 90% by SDS-PAGE
• Species ReactivityHuman
• Immunogen Description220-536aa
• Alternative Names    C1orf7,CIAS1,NALP3,PYPAF1,Angiotensin/vasopressin receptor AII/AVP-like,Caterpiller protein 1.1,Cold autoinflammatory syndrome 1 protein,Cryopyrin,PYRIN-containing APAF1-like protein 1,CLR1.1
• Accession No. Q96P20
  Gene name:NLRP3
• UniprotQ96P20
• Gene ID114548;
• Calculated MW 34.87
• Tag Info His
• Formulation 50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole,10%glycerol(PH8.0)
• Storage Store at -20C. (Avoid repeated freezing and thawing.)
  Repeated freezing and thawing is not recommended. Store working aliquots at 4˚C for up to one week.

May function as an inducer of apoptosis. Interacts selectively with ASC and this complex may function as an upstream activator of NF-kappa-B signaling. Inhibits TNF-alpha induced activation and nuclear translocation of RELA/NF-KB p65. Also inhibits transcriptional activity of RELA. Activates caspase-1 in response to a number of triggers including bacterial or viral infection which leads to processing and release of IL1B and IL18.

Repeated freezing and thawing is not recommended. Store working aliquots at 4˚C for up to one week.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting