• Product NameSorafenib tosylate
• Brief DescriptionInhibitors
• Purification99.00%
• Biological ActivitySorafenib tosylate (BAY 43-9006) is a potent inhibitor of Raf-1 with IC50 values of 6 nM, 22 nM and 90 nM for Raf-1, B-Raf, and VEGFR2 respectively, BAY 43-9006 suppresses both wild-type and V599E mutant BRAF activity in vitro.
• Target Namec-Kit inhibitor; FGFR inhibitor; FLT inhibitor; PDGFR inhibitor; Raf inhibitor; VEGFR inhibitor
• CAS No. 475207-59-1
• Calculated MW 637.03
• Formulation C21H16ClF3N4O3C7H8O3S
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CC1=CC=C(C=C1)S(O)(=O)=O.CNC(=O)C1=NC=CC(OC2=CC=C(NC(=O)NC3=CC(=C(Cl)C=C3)C(F)(F)F)C=C2)=C1
  Pathways:Angiogenesis; MAPK; Tyrosine Kinase/Adaptors
  Receptor:c-Kit; FGFR1; FLT3; mPDGFRβ; PDGFRβ; B-Raf; B-Raf (V599E); Raf-1; VEGFR2; VEGFR2/Flk1
  Boling pt:
  Melting pt:523.3C
  Solubility:Water: 0.01 mg/mL (0.01 mM); DMSO: 127 mg/mL (199.36 mM)
  Appearance:White Crystalline Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Wilhelm SM, et al. Y Res, 2004, 64(19), 7099-7109.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting