- Product NameMRT67307
- Brief DescriptionInhibitors
- Purification99.00%
- Biological ActivityMRT67307 is a kinase inhibitor that has been shown to inhibit TBK1, MARK1-4, IKKε, and NUAK1 (IC50?values are 19, 27-52, 160, and 230 nM, respectively), the salt-inducible kinases (SIKs; IC50s = 250, 67, and 430 nM for SIK1, SIK2, and SIK3, respectively) and ULK1 and ULK2 (IC50s = 45 and 38 nM, respectively). MRT67307 prevents the phosphorylation of IRF3 and the production of IFN-β and increases toll-like receptor-induced IL-10 and IL-1ra secretion in macrophages.?Through its effects on ULK1 and ULK2, MRT67307 blocks autophagy.
- Target NameIκB/IKK inhibitor
- CAS No. 1190378-57-4
- Calculated MW 464.62
- Formulation C26H36N6O2
- Storage 3 years -20˚C powder;2 years -80˚C in solvent;
