• Product NameMethazolamide
• Brief DescriptionInhibitors
• Purification99.00%
• Biological ActivityMethazolamide is a carbonic anhydrase inhibitor used to treat glaucoma. Target: Carbonic Anhydrase Methazolamide is a carbonic anhydrase inhibitor with Ki of 50 nM, 14 nM and 36 nM for hCA I, hCA II and bCA IV isoforms, respectively.
• Target NameCarbonic Anhydrase inhibitor
• CAS No. 554-57-4
• Calculated MW 236.27
• Formulation C5H8N4O3S2
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:CN1N=C(SC1=NC(C)=O)S(N)(=O)=O
  Pathways:Metabolism
  Receptor:bCAIV; hCAI; hCAII
  Boling pt:402C
  Melting pt:208C
  Solubility:Ethanol: 3 mg/mL (12.69 mM); DMSO: 47 mg/mL (198.92 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Casini A, et al. Bioorg Med Chem Lett, 2003, 13(5), 841-845.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting