• Product NameVagistat
• Brief DescriptionInhibitors
• Purification98.56%
• Biological ActivityTioconazole is an antifungal medication of the Imidazole class used to treat infections caused by a fungus or yeast. Tioconazole topical (skin) preparations are also available for ringworm, jock itch, athlete's foot, and tinea versicolor or "sun fungus". Tioconazole interacts with 14-alpha demethylase, a cytochrome P-450 enzyme that converts lanosterol to ergosterol, an essential component of the yeast membrane. In this way, tioconazole inhibits ergosterol synthesis, resulting in increased cellular permeability.
• Target NameAntifection antagonist
• CAS No. 65899-73-2
• Calculated MW 387.71
• Formulation C16H13Cl3N2OS
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Immunology
  SMILES:ClC1=C(COC(CN2C=CN=C2)C2=C(Cl)C=C(Cl)C=C2)C=CS1
  Pathways:Microbiology&virology
  Receptor:14-α Demethylase
  Boling pt:534.5C
  Melting pt:
  Solubility:Ethanol: 78 mg/mL (201.18 mM); DMSO: 78 mg/mL (201.18 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Ballard SA, et al. Biochem Pharmacol. 1988 Dec 15;37(24):4643-51.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting