• Product NameQuetiapin
• Brief DescriptionInhibitors
• Purification99.50%
• Biological ActivityQuetiapine is indicated for the treatment of schizophrenia as well as for the treatment of acute manic episodes associated with bipolar I disorder. The antipsychotic effect of quetiapine is thought by some to be mediated through antagonist activity at dopamine and serotonin receptors. Specifically the D1 and D2 dopamine, the alpha 1 adrenoreceptor and alpha 2 adrenoreceptor, and 5-HT1A and 5-HT2 serotonin receptor subtypes are antagonized. Quetiapine also has an antagonistic effect on the histamine H1 receptor.
• Target Name5-HT Receptor antagonist; AChR antagonist; Adrenergic Receptor antagonist; Dopamine Receptor antagonist; Histamine Receptor antagonist
• CAS No. 111974-69-7
• Calculated MW 383.51
• Formulation C21H25N3O2S
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Nervous system
  SMILES:OCCOCCN1CCN(CC1)C1=NC2=CC=CC=C2SC2=CC=CC=C12
  Pathways:GPCR/G Protein; Neuroscience; Immunology/Inflammation
  Receptor:5-HT; mAChR; Adrenergic Receptor; Dopamine; H1 receptor
  Boling pt:556.5C?
  Melting pt:172-174C
  Solubility:DMSO: 36 mg/mL;Water: <1 mg/mL
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Nasrallah HA. Mol Psychiatry. 2008 Jan;13(1):27-35.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting