• Product NameMaprotiline hydrochloride
• Brief DescriptionInhibitors
• Purification99.50%
• Biological ActivityMaprotiline is a tetracyclic antidepressant with similar pharmacological properties to tricyclic antidepressants (TCAs). Similar to TCAs, maprotiline inhibits neuronal norepinephrine reuptake, possesses some anticholinergic activity, and does not affect monoamine oxidase activity. It differs from TCAs in that it does not appear to block serotonin reuptake. Maprotiline may be used to treat depressive affective disorders, including dysthymic disorder (depressive neurosis) and major depressive disorder. Maprotiline is effective at reducing symptoms of anxiety associated with depression.
• Target Name5-HT Receptor antagonist; AChR antagonist; Adrenergic Receptor antagonist; Histamine Receptor antagonist; Norepinephrine inhibitor
• CAS No. 10347-81-6
• Calculated MW 313.86
• Formulation C20H24ClN
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Nervous system
  SMILES:Cl.CNCCCC12CCC(C3=CC=CC=C13)C1=CC=CC=C21
  Pathways:GPCR/G Protein; Neuroscience; Immunology/Inflammation
  Receptor:5-HT; mAChR; Adrenergic Receptor; H1 receptor; Noradrenaline transporter (Sodium-dependent)
  Boling pt:399.6C?
  Melting pt:230-232C
  Solubility:Ethanol: 24 mg/mL (76.46 mM); DMSO: 63 mg/mL (200.72 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Buckley NA, McManus PR. Drug Saf. 1998 May;18(5):369-81.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting