• Product NamePemetrexed acid
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityPemetrexed is a Folate Analog Metabolic Inhibitor. The mechanism of action of pemetrexed is as a Folic Acid Metabolism Inhibitor.
• Target NameDHFR inhibitor; DNA/RNA Synthesis inhibitor
• CAS No. 137281-23-3
• Calculated MW 427.41
• Formulation C20H21N5O6
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:C1=CC(=CC=C1CCC2=CNC3=C2C(=O)N=C(N3)N)C(=O)N[C@@H](CCC(=O)O)C(=O)O
  Pathways:DNA Damage/DNA Repair; Metabolism
  Receptor:DHFR; GARFT; Thymidylate synthase
  Boling pt:
  Melting pt:129C
  Solubility:DMSO: 1mg/mL Water: 94 mg/mL Ethanol <1 mg/mL
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Shih C, et al. Y Res. 1997, 57(6), 1116-1123.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting