• Product NamePemetrexed disodium
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityPemetrexed (brand name Alimta) is a chemotherapy drug manufactured and marketed by Eli Lilly and Company. Its indications are the treatment of pleural mesothelioma as well as non-small cell lung Y.
• Target NameDHFR inhibitor; DNA/RNA Synthesis inhibitor
• CAS No. 150399-23-8
• Calculated MW 471.37
• Formulation C20H19N5Na2O6
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:C1=CC(=CC=C1CCC2=CNC3=C2C(=O)N=C(N3)N)C(=O)N[C@@H](CCC(=O)[O-])C(=O)[O-].[Na+].[Na+]
  Pathways:DNA Damage/DNA Repair; Metabolism
  Receptor:DHFR; GARFT; Thymidylate synthase
  Boling pt:
  Melting pt:36-38C
  Solubility:Water: 94 mg/mL (199.41 mM)
  Appearance:White Crystal
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Teicher BA, et al. Clin Y Res. 2000 Mar;6(3):1016-23.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting