• Product NameManidipine dihydrochloride
• Brief DescriptionInhibitors
• Purification99.50%
• Biological ActivityManidipine dihydrochloride is a dihydropyridine compound and a calcium channel blocker for Ca2+ current with IC50 of 2.6 nM.
• Target NameCalcium Channel antagonist
• CAS No. 89226-75-5
• Calculated MW 683.62
• Formulation C35H40Cl2N4O6
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cardiovascular System
  SMILES:[H+].[H+].[Cl-].[Cl-].COC(=O)C1=C(C)NC(C)=C(C1C1=CC(=CC=C1)[N+]([O-])=O)C(=O)OCCN1CCN(CC1)C(C1=CC=CC=C1)C1=CC=CC=C1
  Pathways:Membrane transporter/Ion channel
  Receptor:Calcium Channel
  Boling pt:722C
  Melting pt:
  Solubility:DMSO: 21 mg/mL (30.71 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Tohse N, et al. Eur J Pharmacol, 1993, 249(2), 231-233.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting