- Product NameChloroquine diphosphate
- Brief DescriptionInhibitors
- Purification99.00%
- Biological ActivityChloroquine diphosphate is used as an antimalarial drug and also functions to increase sensitivity of tumor cells to radiation and chemotherapy via inducing autophagy . Chloroquine diphosphate has been reported as an adjuvant for radiation and chemotherapy for inducing cell autophagy to anti-Y cells proliferation or metastasis . The mechanism of chloroquine diphosphate inducing cells autophagy is arresting cells in G1, up-regulates the expression of p27 and p53 while down-regulates the expression of CDK2 and cyclin D1 . Apart from anti-malarial, chloroquine diphosphate also has long been reported functioning in cell apoptosis. Pretreated CNE-2 human nasopharyngeal carcinoma cells with chloroquine diphosphate enhanced ionizing radiation induced cell apoptosis via increasing cells autophagic ratio . When treated with mouse breast Y 4T1 cells, chloroquine diphosphate treatment inhibited cellular proliferation and viability which resulted in cells apoptosis in a time- and dose- dependent manner . In human colon Y DLD-1 cells, combination of 5-FU and chloroquine diphosphate could inhibit cells proliferation via inducing autophagy
- Target NameATM/ATR activator
- CAS No. 50-63-5
- Calculated MW 515.87
- Formulation C18H26CLN32(H3PO4)
- Storage 3 years -20˚C powder;2 years -80˚C in solvent;
