• Product NameRanolazine dihydrochloride
• Brief DescriptionInhibitors
• Purification99.50%
• Biological ActivityRanolazine(RS-43285) is an antianginal agent with antiarrhythmic properties that achieves its effects via a novel mechanism of action (inhibition of the late phase of the inward sodium current), without affecting heart rate or blood pressure (BP).
• Target NameCalcium Channel inhibitor; Sodium Channel inhibitor
• CAS No. 95635-56-6
• Calculated MW 500.46
• Formulation C24H35Cl2N3O4
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cardiovascular System
  SMILES:Cl.Cl.COC1=CC=CC=C1OCC(O)CN1CCN(CC(=O)NC2=C(C)C=CC=C2C)CC1
  Pathways:Membrane transporter/Ion channel
  Receptor:Calcium Channel; Sodium Channel
  Boling pt:624.1C
  Melting pt:222-229.5C
  Solubility:Water: 100 mg/mL (199.81 mM); DMSO: 100 mg/mL (199.81 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Undrovinas AI, et al. J Cardiovasc Electrophysiol, 2006, 17 Suppl 1, S169-S177.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting