• Product NameTamsulosin hydrochloride
• Brief DescriptionInhibitors
• Purification99.76%
• Biological ActivityTamsulosin is a selective antagonist at alpha-1A and alpha-1B-adrenoceptors in the prostate, prostatic capsule, prostatic urethra, and bladder neck. At least three discrete alpha1-adrenoceptor subtypes have been identified: alpha-1A, alpha-1B and alpha-1D; their distribution differs between human organs and tissue. Approximately 70% of the alpha1-receptors in human prostate are of the alpha-1A subtype. Blockage of these receptors causes relaxation of smooth muscles in the bladder neck and prostate.
• Target NameAdrenergic Receptor antagonist
• CAS No. 106463-17-6
• Calculated MW 444.97
• Formulation C20H29ClN2O5S
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Endocrine system
  SMILES:CCOC1=CC=CC=C1OCCN[C@H](C)CC2=CC(=C(C=C2)OC)S(=O)(=O)N.Cl
  Pathways:GPCR/G Protein
  Receptor:α1A-adrenergic receptor; α1B-adrenergic receptor; α1D-adrenergic receptor
  Boling pt:595.5C
  Melting pt:228-230C
  Solubility:Water: 215.9 mg/L
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Abrams P, et al. Br J Urol. 1997 Oct; 80(4):587-96.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting