• Product NameLosartan potassium
• Brief DescriptionInhibitors
• Purification99.50%
• Biological ActivityLosartan is an angiotensin II receptor antagonist, competes with the binding of angiotensin II to AT1 receptors with IC50 of 20 nM. IC50 Value: 20 nM Target: Angiotensin Receptor in vitro: Pre-incubation with losartan (LOS), an antagonist of
• Target NameRAAS antagonist
• CAS No. 124750-99-8
• Calculated MW 461.01
• Formulation C22H22ClKN6O
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cardiovascular System
  SMILES:[K].CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=C1)C1=CC=CC=C1C1=NN=N[N-]1
  Pathways:Endocrinology/Hormones
  Receptor:AT1 receptor
  Boling pt:134C
  Melting pt:?69C
  Solubility:Ethanol: 92 mg/mL (199.12 mM); Water: 92 mg/mL (199.12 mM); DMSO: 92 mg/mL (199.12 mM)
  Appearance:White Crystal
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Burnier M, et al. Circulation, 2001, 103, 904-912.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting