• Product NameGemcitabine
• Brief DescriptionInhibitors
• Purification99.00%
• Biological ActivityGemcitabine(LY-188011; NSC 613327) is a DNA synthesis inhibitor with IC50 of 50 nM, 40 nM, 18 nM and 12 nM in PANC1, MIAPaCa2, BxPC3 and Capan2 cells, respectively.
• Target NameAutophagy activator; DNA/RNA Synthesis inhibitor; Others inhibitor
• CAS No. 95058-81-4
• Calculated MW 263.2
• Formulation C9H11F2N3O4
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:C1=CN(C(=O)N=C1N)[C@H]2C([C@@H]([C@H](O2)CO)O)(F)F
  Pathways:Autophagy; DNA Damage/DNA Repair; Others
  Receptor:Autophagy; Thymidylate synthase; UMP-CMP kinase
  Boling pt:
  Melting pt:168C
  Solubility:DMSO: 15 mg/mL (56.99 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Hertel LW, et al. Y Res, 1990, 50(14), 4417-4422.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting